Serum Proteome Response in Healthy Dogs Following Cannabidiol Administration

A proteomics study by Wutthiwong Theerapan, published on figshare in 2026, compares systemic molecular effects in dogs after oral cannabidiol (CBD) delivery. The dataset contains label-free quantitative proteomics data from 18 healthy dogs after 30 days of CBD administration via three distinct matrices: feed pellets, infused oil, and semi-solid treats. Analysis revealed formulation-specific proteomic signatures and a core metabolic response involving lipid metabolism and redox homeostasis.

Use Cases

• Compare proteomic signatures based on different CBD delivery matrices (feed pellets, oil, treats) mentioned in the description.
• Investigate CBD-mediated modulation of lipid metabolism based on the downregulation of apolipoproteins (APOA4, APOC3, APOC1, APOH).
• Analyze vascular integrity and tissue scaffolding responses based on the upregulation of proteins like TGFB1, PDGFRB, and VWF in high-exposure groups.
• Study immunomodulatory and cytoprotective effects based on markers such as clusterin (CLU) induced in the semi-solid treat group.
• Model the relationship between CBD bioavailability and proteomic remodeling scope as suggested by the study findings.

Strengths

• Data from a controlled study with 18 healthy dogs over a 30-day administration period.
• Proteomic analysis compares three distinct CBD delivery matrices (feed pellets, oil, semi-solid treats).
• Findings include specific protein markers (e.g., APOA4, HBA, TGFB1, CLU) associated with metabolic and vascular responses.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (12.8 KB), indicating limited scope.

Provenance

Source

Wutthiwong Theerapan via figshare.

Collection Method

Label-free quantitative proteomics on serum samples from a controlled canine study.

Freshness

Last updated 2026-05-13 05:55:49.