Table 1: Framework-Mediated Glycan Binding by IGHV4–34 Antibodies

A 1.8 MB DOCX file published on figshare under CC-BY-4.0 license by David B. Langley, last updated March 17, 2026. The dataset likely contains tabular data related to the binding interactions between IGHV4–34 antibodies and foreign and self-glycans, providing insights into autoimmune cold agglutinin disease.

Use Cases

• Analyze the structural role of the FR1 hydrophobic patch in glycan binding based on the described antibody framework.
• Model antibody-antigen interactions for self-reactive glycans like LacNAc based on the described stereochemical similarities.
• Investigate the non-CDR binding mode of IGHV4–34 antibodies based on the described framework-centric engagement mechanism.

Strengths

• File size is precisely 1.8 MB.
• License is clearly defined as CC-BY-4.0.
• Author is explicitly named as David B. Langley.
• Last update timestamp is provided: 2026-03-17 13:07:01.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental or structural biology data, but the specific collection method is not detailed.

Time Range

null

Freshness

Last updated 2026-03-17 13:07:01; freshness should be verified.

Geography

null