Integrated Proteomic and Transcriptomic Profiles from a Rat Model of Anxious Depression

A 20.6 KB document by Lingchang Shi, last updated in May 2026, details proteomic and transcriptomic analyses from a rat model of anxious depression. The research investigates the role of mitochondrial oxidative stress and neuroinflammation, specifically the ROS/TXNIP/NLRP3 signaling pathway, in the hippocampus. The dataset includes results from behavioral tests, molecular analyses, and in vitro validation experiments.

Use Cases

• Identify differentially expressed proteins and transcripts in the hippocampus based on integrated omics profiling.
• Study the relationship between mitochondrial ROS accumulation and neuroinflammation based on the described signaling pathway.
• Validate the role of specific genes like TXNIP in microglial activation and neuronal injury based on the in vitro knockdown experiments.
• Analyze the effects of antioxidant intervention (Mito-TEMPO) on behavioral and molecular pathology based on the described experimental results.

Strengths

• Dataset is associated with a detailed, hypothesis-driven research study published on figshare.
• The underlying research employs a multi-modal approach, integrating proteomics, transcriptomics, and behavioral validation.
• The data is shared under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The primary data file is a 20.6 KB DOCX document, which likely contains a summary of results rather than the raw underlying data tables.
• Row and column counts for any potential underlying data are unknown, limiting suitability assessment for direct computational analysis.
• The description lacks column-level documentation, requiring manual inspection of the document to understand data semantics.

Provenance

Source

Lingchang Shi via figshare

Collection Method

Data generated from a rat model of anxious depression using chronic restraint stress and corticosterone administration, followed by integrated proteomic and transcriptomic analyses.

Freshness

Last updated 2026-05-19 04:20:57; freshness should be verified.