Table 1_Functional characterization of Candida auris DHA1 transporters conferring flucytos

A 24.8 KB document by Sarita Malik, last updated May 8, 2026, under a CC-BY-4.0 license. It presents functional evidence linking two DHA1 family transporters, CauQdr2 and CauMdr1.2, to flucytosine resistance in the critical pathogen Candida auris, including IC₅₀ shift data and the identification of a selective inhibitor.

Use Cases

• Studying transporter-mediated drug resistance mechanisms based on the functional characterization of CauQdr2 and CauMdr1.2.
• Identifying potential drug targets for antifungal intervention based on the described conserved interaction niche in DHA1 transporters.
• Designing combination therapy strategies based on the rationale for incorporating transporter inhibitors like clorgyline with flucytosine.
• Validating structural models of major facilitator superfamily proteins using the ligand-bound interaction data provided.

Strengths

• Provides specific experimental results, including a >2-fold shift in IC₅₀ values for flucytosine resistance.
• Identifies a concrete molecular target (clorgyline as a selective inhibitor of CauMdr1.2) with potential therapeutic implications.
• Clear provenance with author attribution and a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single 24.8 KB document, indicating a very limited scope focused on specific experimental findings.

Provenance

Source

figshare, author Sarita Malik.

Collection Method

Likely contains experimental data and analysis from heterologous expression in Saccharomyces cerevisiae and structural modeling.

Time Range

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Freshness

Last updated 2026-05 08 05:50:38; freshness should be verified.

Geography

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