Table 1_Functional connectivity changes in the thalamocortical network due to neck pain an

A 2026 study by Zhen Gao presents neuroimaging and transcriptomic data from 100 neck pain patients randomized to verum or sham acupuncture groups, with 49 patients per group included in the final analysis. The dataset includes Visual Analog Scale scores, resting-state fMRI functional connectivity data, and gene expression associations from the Allen Human Brain Atlas. Results show specific connectivity changes in the thalamus-anterior cingulate cortex network and enrichment of genes in immune and synaptic pathways.

Use Cases

• Analyzing functional connectivity changes between brain regions like the thalamus and anterior cingulate cortex based on fMRI data.
• Investigating associations between gene expression patterns and neuroimaging-derived connectivity measures.
• Comparing the effects of verum versus sham acupuncture on pain-related brain networks.
• Exploring multi-omics correlations between transcriptomic pathways and functional brain changes.

Strengths

• Data from a randomized controlled trial with 100 initially enrolled participants and 49 per group in the final analysis.
• Integrates multiple data modalities: clinical pain scores (VAS), resting-state fMRI, and transcriptomic data from the Allen Human Brain Atlas.
• Results include specific statistical findings, such as a PLS2 component explaining 39.83% of functional connectivity variance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 75.9 KB, indicating limited scope.

Provenance

Source

figshare, author Zhen Gao.

Collection Method

Data collected from a clinical trial involving resting-state fMRI scans, VAS assessments, and analysis of Allen Human Brain Atlas transcriptome data via Partial Least Squares regression.

Freshness

Last updated 2026-04-28 05:27:39; freshness should be verified.