Vinegar-Processed Cyperi Rhizoma: Molecular Mechanism for Hepatic Targeting

A study by Gui Xu, last updated in May 2026, integrates in silico docking and in vitro experiments to investigate the hepatic-targeting effects of vinegar-processed Cyperi Rhizoma. The research identifies a chemical transformation from cyperene to cyperotundone and demonstrates the modulation of hepatic transporters OAT2 and MRP2. The dataset, shared on figshare, provides the supporting documentation for these findings.

Use Cases

• Study the chemical transformation of botanical ingredients during processing based on the described HS-GC–MS analysis.
• Investigate molecular docking predictions for compound-transporter affinity based on the described in silico methods.
• Analyze cellular uptake of bioactive components using UPLC-QqQ-MS data mentioned in the description.
• Validate binding interactions between processed botanical components and hepatic transporters based on the described ligand fishing assays.
• Model the mechanistic role of OAT2 and MRP2 transporters in hepatic retention based on the described overexpression experiments.

Strengths

• The description provides a detailed mechanistic explanation involving specific transporters OAT2 and MRP2.
• The study integrates multiple experimental methods: in silico docking, HS-GC–MS, UPLC-QqQ-MS, and ligand fishing assays.
• The dataset is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 74.3 KB DOCX file, indicating a very limited scope, likely a document rather than a primary data repository.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare, author Gui Xu.

Collection Method

Integrated in silico docking with in vitro experiments on HepaRG cells.

Freshness

Last updated 2026-05-21 04:31:24; freshness should be verified.