Rat Study Data on L-Se-methylselenocysteine Effects on Gut Microbiota and Toxicity

Sprague–Dawley rats were used in a 90-day chronic toxicity study by Hui Zhang, published on figshare in 2026. The dataset likely contains results from integrated intestinal microbiome and metabolome analysis. It explores dose-dependent and gender-specific responses to L-Se-methylselenocysteine mediated by the gut microbiota-metabolite axis.

Use Cases

• Analyze dose-dependent effects on gut microbiota biodiversity based on the described 0.25–2.25 mg/kg bw/day dosing range
• Investigate gender-specific hepatosplenic injury patterns based on the described high-dose toxicity in female rats
• Model relationships between probiotic abundance and beneficial metabolite synthesis based on the described gut microbiota-metabolite axis
• Assess hematological and serum biochemical indices changes based on the described amelioration of these metrics

Strengths

• Data originates from a controlled 90-day chronic toxicity study
• Includes integrated analysis of microbiome and metabolome
• Explicitly tests a dose range from 0.25 to 2.25 mg/kg bw/day
• Published under an open CC-BY-4.0 license

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is limited to a single species (Sprague–Dawley rats)

Provenance

Source

figshare

Collection Method

Data likely collected from a 90-day chronic toxicity study with integrated microbiome and metabolome analysis.

Freshness

Last updated 2026-03-19 14:03:07; freshness should be verified