Gene Expression Profiles of Dendritic Cells in Systemic Lupus Erythematosus

Table 1_Gene expression profiling of dendritic cell tolerance dysfunction in women with systemic lupus erythematosus.xlsx contains transcriptional profiles of in vitro generated dendritic cells from SLE patients and healthy controls. The dataset, authored by Ana Laura Hernández-Ledesma and last updated in June 2026, is available under a CC-BY-4.0 license on figshare. It is a 2.8 MB Excel file.

Use Cases

• Identify interferon-stimulated gene signatures in SLE based on the description of IFI27, IFI44L, USP18, and IFI6 as central hubs.
• Analyze disruptions in lipid metabolism pathways within tolerogenic dendritic cells from SLE donors.
• Investigate defects in IL-10 signaling by examining IL10RA expression and IRF4 activity in SLE monocyte-derived dendritic cells.
• Compare transcriptional profiles between SLE patients and healthy controls to find disease-specific pathway disruptions.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• File size is 2.8 MB, indicating a focused and manageable dataset for analysis.
• Description provides specific biological findings, such as the role of key interferon-stimulated genes and altered lipid metabolism pathways.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific in vitro generation protocol and patient cohort used.

Provenance

Source

Ana Laura Hernández-Ledesma via figshare.

Collection Method

Transcriptional profiles were generated from in vitro derived dendritic cells from monocytes of SLE individuals and healthy controls.

Freshness

Last updated 2026-06-02 09:03:45; freshness should be verified.