Gene-Environment Interactions for Osteoporosis Risk in 609 Mexican Women

609 Mexican women, including 169 with osteoporosis and 205 with hip fracture, were genotyped for variants in seven genes related to bone metabolism. Antonio Miranda-Duarte published this case-control study on figshare in March 2026. The data includes odds ratios for specific genotypes and results from multifactor dimensionality reduction analysis for gene-gene and gene-environment interactions.

Use Cases

• Modeling osteoporosis risk based on specific RANK and ESR1 single-nucleotide variants mentioned in the results.
• Analyzing gene-gene interactions for hip fracture risk based on the identified model involving ESR1, IL6R, IL1β, and RANKL.
• Investigating gene-environment interactions between CYP19A1 variants, IL1β, and fracture probability scores.
• Validating genetic association findings for bone diseases in a Mexican population cohort.

Strengths

• Includes specific odds ratios for risk associations, such as RANK rs3018362 AA genotype (OR=2.76) for osteoporosis.
• Reports cross-validation consistency scores (CVC) for interaction models, like 10/10 for a key gene-gene interaction.
• Focuses on an understudied demographic (Mexican women) for osteoporosis genetics.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 49.4 KB, indicating limited scope.

Provenance

Source

Antonio Miranda-Duarte via figshare.

Collection Method

Case-control study using real-time PCR with TaqMan probes for genotyping and multifactor dimensionality reduction software for interaction analysis.

Time Range

null

Freshness

Last updated 2026-03-18 10:17:55; freshness should be verified.

Geography

Mexican women.