Table 1_Genes causative of primary immunodeficiency are risk factors for and are over-expr

A 453-gene database of primary immunodeficiency (PID) genes was developed and analyzed for genetic association and differential expression in systemic lupus erythematosus (SLE). The dataset, authored by Haley Davis and last updated in March 2026, includes results from protein-protein interaction clustering, differential expression analysis across multiple sample types, and machine learning classifiers built using PID genes. These classifiers achieved reported accuracies of 0.80 for classifying lupus from healthy controls and 0.74 for classifying active from inactive lupus.

Use Cases

• Identifying novel SLE risk genes based on overlap with known primary immunodeficiency genes.
• Analyzing differential expression patterns of PID genes in specific immune cell subsets like T cells and monocytes.
• Training machine learning classifiers to predict SLE disease status using PID gene expression data.
• Mapping protein-protein interaction networks of PID genes to discover functional clusters relevant to lupus pathogenesis.
• Investigating associations between PID gene expression and measures of lupus disease activity.

Strengths

• Includes a defined set of 453 primary immunodeficiency genes.
• Reports machine learning classifier accuracies of 0.80 and 0.74 for specific prediction tasks.
• Analyzes data from multiple sample types, including whole blood and immune cell-specific samples.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small (180.4 KB), indicating limited scope, likely containing summary results rather than raw experimental data.

Provenance

Source

figshare, author Haley Davis.

Collection Method

A comprehensive database of PID genes was developed, followed by clustering, differential expression analysis, and machine learning modeling.

Time Range

Temporal coverage is not specified.

Freshness

Last updated 2026-03-18 10:09:45; freshness should be verified.

Geography

Spatial coverage is not specified.