Genetic Determinants of AMD in Middle Eastern Populations: A Systematic Review

Middle Eastern populations are the focus of this systematic review summarizing evidence on genetic variants associated with age-related macular degeneration (AMD). The review analyzed 28 studies covering 4,247 AMD cases and 3,447 controls from five countries, with the most frequently studied genes being CFH, ARMS2, and HTRA1. It was authored by Naif S. Sannan and last updated in May 2026.

Use Cases

• Conducting meta-analyses on AMD-associated genetic variants based on the aggregated study results.
• Comparing genetic risk factors for AMD across different populations based on the Middle Eastern cohort data.
• Identifying research gaps in AMD genetics for Middle Eastern countries based on the review's findings.
• Investigating genotype-phenotype correlations for neovascular AMD based on the reported associations with ARMS2 and HTRA1 variants.

Strengths

• Aggregates data from 28 studies covering a total of 7,694 participants (4,247 cases and 3,447 controls).
• Provides specific odds ratios and p-value ranges for key variants like CFH Y402H (rs1061170).
• Explicitly lists the five Middle Eastern countries (Turkey, Iran, Israel, Jordan, Egypt) included in the analysis.

Limitations

• The dataset is a 13.0 KB document, indicating it is a summary review rather than a primary data repository.
• Column-level documentation for any underlying data is absent; field semantics must be inferred from the review text.
• The genetic landscape is described as incompletely characterized, with many Middle Eastern countries lacking published data.

Provenance

Source

figshare, authored by Naif S. Sannan.

Collection Method

Systematic literature review of PubMed, Web of Science Core Collection, and Medline databases.

Freshness

Last updated 2026-05-07 22:01:46

Geography

Middle East (specifically Turkey, Iran, Israel, Jordan, Egypt)