IL-18 Genetic Variation and Sepsis Prognosis: Multicenter Hospital Study

784 sepsis patients and 776 healthy controls were genotyped for the IL-18 rs187238 polymorphism to investigate its role in sepsis mortality and inflammatory responses. The study, authored by Zhuoji Li and last updated in June 2026, found the G allele was associated with higher 28-day ICU mortality and increased IL-18 expression. Functional assays confirmed the variant's impact on promoter activity and its link to elevated levels of cytokines like IL-1β, IL-6, and ICAM-1.

Use Cases

• Train models to predict sepsis mortality risk based on genetic polymorphism and cytokine levels mentioned in the description.
• Analyze associations between specific genotypes (CC, CG, GG) and inflammatory marker expression like IL-18, IL-1β, and IL-6.
• Validate the rs187238-G allele as a prognostic biomarker for sepsis using clinical and genetic data from the multicenter study.

Strengths

• Dataset is derived from a multicenter study involving 1,560 total participants (784 patients, 776 controls).
• Analysis includes functional validation via dual-luciferase assays and cytokine measurement via ELISA/qRT-PCR, as described.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 21.2 KB, indicating limited scope, likely containing summary results rather than raw patient-level data.

Provenance

Source

figshare

Collection Method

Multicenter case-control study with genotyping using imLDR™ multiplex SNP method, ELISA, qRT-PCR, and dual-luciferase assays.

Freshness

Last updated 2026-06-02 22:02:12; freshness should be verified.