Genome-Wide Association Study of Atopic and Autoimmune Comorbidities in Alopecia Areata

Marisol Herrera-Rivero's dataset contains results from an exploratory genome-wide association study investigating genetic links between alopecia areata and comorbid chronic inflammatory disorders. The study analyzed 110 to 1,302 Central European AA cases with comorbidities and 1,030 controls without, focusing on atopic and autoimmune conditions. It was last updated on 2026-04-17 and is shared under a CC-BY-4.0 license.

Use Cases

• Identify potential genetic loci associated with comorbid autoimmune conditions based on reported variant and gene-level p-values.
• Investigate shared biological pathways for atopy and autoimmunity based on the network analyses of cytokine and hormone signaling mentioned.
• Validate previously implicated genes like PHF11 in the context of alopecia areata comorbidity.
• Use exploratory association thresholds (p_variant<1x10^-5, p_gene<0.001) for hypothesis generation in follow-up genetic studies.

Strengths

• Includes genetic association data for a specific cohort of 110 to 1,302 Central European alopecia areata cases with comorbidities.
• Analyzes multiple specific conditions: asthma, atopic dermatitis, rhinitis, vitiligo, and Hashimoto’s thyroiditis.
• Provides initial mechanistic insights from network analyses, as described in the results.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (81.0 KB), indicating limited scope, likely containing summary statistics rather than raw genetic data.

Provenance

Source

Marisol Herrera-Rivero via figshare.

Collection Method

Exploratory genome-wide association study in a Central European cohort, with comorbidity status self-reported.

Freshness

Last updated 2026-04-17 05:21:52; freshness should be verified.

Geography

Central Europe