Table 1_Genome-wide association study of myopia progression in Chinese adolescents and app

A genome-wide association study (GWAS) dataset from 294 Chinese adolescents who completed a 2-year follow-up, aiming to identify genetic risk factors for myopia progression. The data includes results from a two-stage study (discovery cohort: N=176; replication cohort: N=118) and the construction of single-ancestry and cross-ancestry polygenic risk score (PRS) models. The dataset was authored by Qinye Liu and last updated on April 21, 2026.

Use Cases

• Identifying genetic loci associated with myopia progression based on GWAS results from Chinese adolescents.
• Developing and evaluating polygenic risk score (PRS) models for predicting myopia progression risk, as described in the study.
• Comparing the predictive performance of single-ancestry (East Asian) and cross-ancestry PRS models for myopia.
• Conducting functional annotation and MAGMA analysis to explore the biological relevance of identified genetic loci.

Strengths

• Includes data from a two-stage GWAS with a discovery cohort of 176 individuals and a replication cohort of 118 individuals.
• Reports specific performance metrics for PRS models, such as an R² of 5.69%, an odds ratio of 1.61, and an AUC of 0.66 for the East Asian model.
• Identifies seven novel suggestive loci associated with myopia progression, including FSTL5, SMARCA2, and CRY1.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in scale at 57.9 KB, indicating limited data volume.

Provenance

Source

figshare, author Qinye Liu.

Collection Method

Genotyping was performed using the Asian Screening Array chip, followed by a two-stage genome-wide association study (GWAS).

Time Range

The study involved a 2-year follow-up of participants; specific collection years are not stated.

Freshness

Last updated 2026-04-21 11:20:41; freshness should be verified.

Geography

Data is from Chinese adolescents, with genetic reference data also from a European population in the UK Biobank.