NBS-LRR Gene Family in Sponge Gourd for Disease Resistance

A genome-wide analysis identified 89 NBS-LRR genes in the sponge gourd (Luffa cylindrica) plant. The research, conducted by Xiaolin Yang and published in 2026, classifies these genes into seven subfamilies and analyzes their roles in resistance to Fusarium wilt and ToLCNDV. The work provides foundational data for molecular breeding.

Use Cases

• Classify NBS-LRR genes into subfamilies (TNL, CNL, N, etc.) based on conserved domain and motif analysis.
• Identify candidate genes for Fusarium wilt resistance by analyzing the nine genes linked to this trait in the disease response data.
• Identify candidate genes for ToLCNDV resistance by analyzing the six genes associated with this trait in the disease response data.
• Study gene expression patterns by examining tissue-specific expression data showing highest activity in roots.
• Analyze evolutionary relationships through phylogenetic clades and inter-species synteny data, such as the 18 orthologous pairs with cucumber.

Strengths

• Identifies a specific set of 89 NBS-LRR genes with detailed subfamily classification.
• Provides functional insights by linking 15 specific genes to resistance against two major diseases (ToLCNDV and Fusarium wilt).
• Includes evolutionary context through intra- and inter-species synteny analysis, identifying 18 orthologous pairs with cucumber.

Limitations

• The dataset is very small at 28.8 KB, containing summary analysis rather than raw sequence or expression matrices.
• No raw columnar data or sample records are provided, limiting direct computational analysis.
• The scope is limited to a single plant species (Luffa cylindrica), reducing broad applicability.

Provenance

Source

Xiaolin Yang via figshare.

Collection Method

Genome-wide bioinformatics analysis and transcriptome data mining.

Freshness

Last updated in April 2026.