Gene Expression Analysis of lncRNAs in Primary Sjögren's Syndrome

A genome-wide gene expression dataset from 126 minor salivary gland samples, comprising 92 patients with primary Sjögren's syndrome and 34 controls. The data was generated by Zhongshan Li via deep stranded total transcriptome sequencing and last updated in April 2026. It includes a constructed competing endogenous RNA network of 3,035 lncRNAs and 10,838 coding genes.

Use Cases

• Constructing competing endogenous RNA (ceRNA) networks based on shared miRNA binding sites and gene-expression correlations.
• Identifying differentially expressed lncRNAs and coding genes between disease and control groups.
• Investigating the regulatory roles of specific lncRNAs (e.g., BISPR, LINC00926, HCP5) in dysregulated pathways.
• Correlating lncRNA expression levels with clinical features of primary Sjögren's syndrome.

Strengths

• Includes a substantial sample size of 126 minor salivary gland samples.
• Contains a genome-wide ceRNA network comprising 3,035 lncRNAs and 10,838 coding genes.
• Experimental validation was performed for three key lncRNAs, supporting functional predictions.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small in file size (19.0 KB), suggesting it may contain summary or processed results rather than raw sequencing data.

Provenance

Source

figshare, author Zhongshan Li

Collection Method

Deep stranded total transcriptome sequencing performed on minor salivary gland samples.

Time Range

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Freshness

Last updated 2026-04-15 05:33:21; freshness should be verified.

Geography

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