Genomic Mutations Linked to Cefiderocol Resistance in Klebsiella Pneumoniae from UAE

282 Klebsiella pneumoniae strains from the United Arab Emirates were tested for antibiotic susceptibility, with 96 undergoing whole-genome sequencing. The analysis identified mutations in oxidative stress, iron regulation, and efflux pump pathways associated with resistance to the novel antibiotic cefiderocol. The dataset, authored by Lana Daoud and last updated in May 2026, provides a network view of multi-pathway resistance mechanisms.

Use Cases

• Identify genomic biomarkers for cefiderocol resistance based on mutations in iron uptake genes like cirA.
• Analyze co-mutation networks linking oxidative stress, efflux, and DNA repair pathways in high-risk bacterial clones.
• Correlate specific mutations in the OxyR regulon with minimum inhibitory concentration (MIC) values for cefiderocol.
• Investigate the genomic basis of clonal evolution in Klebsiella pneumoniae based on sequence type (ST) data.

Strengths

• Includes phenotypic susceptibility data for 282 bacterial strains.
• Provides whole-genome sequencing data for a representative subset of 96 strains.
• Analyzes 51 genes across six functional categories, including OxyR, SoxRS, and efflux pumps.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the United Arab Emirates sample.

Provenance

Source

figshare

Collection Method

Whole-genome sequencing and bioinformatic analysis of clinical isolates.

Freshness

Last updated 2026-05-15 05:27:51

Geography

United Arab Emirates