Genomic Signatures of Cardiac Glycoside Adaptation in Three Insect Orders

A genomic dataset by Kangli Zhu, uploaded to figshare on 2026-04-21, explores convergent molecular adaptations to toxic cardiac glycosides across insect species. The 68.0 KB Excel file likely contains results from whole-genome sequence analyses, including gene family expansions and candidate genes under positive selection. It supports findings from CRISPR-Cas9 experiments on Drosophila lines.

Use Cases

• Identifying convergent gene family expansions based on mentions of stable fatty acyl-CoA reductase, CG5065, carboxylesterases, and gustatory receptors.
• Analyzing candidate genes under positive selection in cardiac glycoside-adapted insect species.
• Studying the functional impact of specific amino acid substitutions, such as in the Gliotactin (Gli) gene, on epithelial permeability and toxin sequestration.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Description details specific genomic analyses and experimental validation using CRISPR-Cas9 and transmission electron microscopy.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 68.0 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Analysis of whole genome sequences from CG-adapted insect species, supplemented by CRISPR-Cas9 knock-in experiments.

Freshness

Last updated 2026-04-21 22:01:28; freshness should be verified.