Mycoplasma Pneumoniae Genomic Surveillance Data from Russia 2024-2025

January 2024 to June 2025 surveillance data covers molecular analysis of 482 nasopharyngeal swabs from community-acquired pneumonia patients in Russia. It includes results for Mycoplasma pneumoniae detection, co-infections with bacteria like H. influenzae and viruses like RSV, and genetic mutations linked to macrolide resistance. The dataset contains findings from PCR, ELISA, and high-throughput sequencing of genes including mgpA, 23S, parC, and gyrA.

Use Cases

• Analyze geographic heterogeneity in macrolide resistance rates using the A2063G mutation data across Russian regions
• Investigate patterns of bacterial co-infections, such as H. influenzae and S. pneumoniae prevalence, relative to MP-positive samples
• Perform phylogenetic analysis on mgpA gene sequences to classify P1 type 1 versus type 2 clades
• Correlate viral co-infection status, including RSV and RV, with patient outcomes or MP detection rates
• Model the association between specific point mutations (A2064G, A2064C) and regional antibiotic resistance profiles

Strengths

• Data is derived from 482 patient nasopharyngeal swab samples analyzed with multiple diagnostic methods
• Includes genetic sequencing results for complete mgpA, 23S, parC, parE, gyrA, and gyrB genes
• Provides co-infection rates for specific pathogens: 27.8% bacterial, with H. influenzae at 19.7% and S. pneumoniae at 13.1%
• Reports a clear macrolide resistance rate of 23% linked to the A2063G mutation and details on rarer point mutations

Limitations

• Limited to 482 samples, which may constrain statistical power for subgroup or rare mutation analysis
• Geographic coverage is within Russia only, limiting generalizability to other populations
• Sample size for ELISA confirmation (75 serum samples) is smaller than the main PCR cohort

Provenance

Source

Elena V. Korneenko via figshare

Collection Method

Molecular genetic surveillance using real-time PCR, high-throughput sequencing of specific genes, and ELISA serology

Time Range

January 2024 to June 2025

Freshness

Covers January 2024 to June 2025; last updated March 2026.

Geography

Various regions of the Russian Federation