Golden Retriever VOC Exposure and Lymphoma Study with 60 Dogs and Two Time Points

A study by Ashleigh N. Tindle investigates volatile organic compound (VOC) exposure in golden retrievers with and without multicentric lymphoma. It includes data from 60 dogs (30 cases, 30 controls) at two time points: diagnosis and one year prior, measuring urinary metabolites for benzene, xylene, and 1,3-butadiene. The dataset was last updated on 2026-04 -13.

Use Cases

• Associating secondhand smoke exposure (via urinary cotinine) with canine lymphoma based on the reported 6 of 30 cases testing positive.
• Modeling genotoxic thresholds for benzene and xylene in canine cells based on the in vitro concentrations (≥10 uM and ≥0.5 uM) described.
• Comparing estimated in vivo blood concentrations of VOCs to established genotoxic levels using reverse dosimetry methods mentioned.
• Analyzing longitudinal changes in VOC metabolite levels from samples taken one year prior to diagnosis versus at diagnosis.

Strengths

• Includes matched case-control data for 60 golden retrievers.
• Provides longitudinal measurements at two distinct time points for each subject.
• Reports specific genotoxic concentration thresholds for benzene (≥10 uM) and xylene (≥0.5 uM) in canine cells.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small at 20.9 KB, indicating limited scope.
• Data may reflect bias inherent to the specific breed (golden retriever) and study design.

Provenance

Source

figshare

Collection Method

Measured stable urinary metabolites of VOCs and performed in vitro genotoxicity assays on canine peripheral blood mononuclear cells.

Time Range

Samples were taken at the time of diagnosis and one year prior.

Freshness

Last updated 2026-04-13 04:31:19; freshness should be verified.

Geography

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