Gestational Erythritol Exposure Effects on Ovarian Function in Wistar Rats

A research document details a study on the transgenerational effects of the artificial sweetener erythritol on ovarian health in Wistar rats. The study, authored by Amina Fallata and published on figshare in 2026, administered erythritol to pregnant rats and analyzed ovarian morphology and molecular markers in their F1 and F2 offspring. Results indicate disrupted folliculogenesis, elevated oxidative stress, and suppressed autophagy and PI3K signaling across generations.

Use Cases

• Study the impact of artificial sweeteners on ovarian development based on histological and molecular data.
• Investigate transgenerational epigenetic effects of gestational exposure based on reduced DNA methylation in F2 offspring.
• Analyze the relationship between oxidative stress and follicular competence based on MDA, SOD, and GSH activity levels.
• Model disruptions in autophagy and cell survival signaling pathways based on LC3, Atg5, and PI3K-p85 expression data.

Strengths

• The study design includes a transgenerational component, analyzing F1 and F2 offspring.
• Specific dosages (0.4 or 4 g/kg/day) and exposure window (gestational day 6 until parturition) are clearly defined.
• Multiple molecular pathways (oxidative stress, autophagy, PI3K signaling, DNA methylation) are evaluated.

Limitations

• The dataset is a 13.4 KB DOCX file, suggesting limited raw data and scope.
• Column-level documentation is absent; field semantics must be inferred from the research paper.
• Data is derived from a specific animal model (Wistar rats), which may limit direct translation to human health.

Provenance

Source

Amina Fallata via figshare.

Collection Method

Experimental study administering erythritol to pregnant Wistar rats and analyzing offspring.

Freshness

Last updated 2026-05-14 14:27:31.