GLIS3 Expression and Clinical Outcomes in Stomach Adenocarcinoma

A clinical cohort of 133 paired stomach adenocarcinoma tissues was analyzed by Qi Xiao, with data last updated in May 2026. The dataset includes GLIS3 protein expression levels from immunohistochemistry and associated transcriptomic data from public sources like The Cancer Genome Atlas. It links GLIS3 expression to adverse clinicopathological features and patient survival outcomes.

Use Cases

• Assessing GLIS3 as a prognostic biomarker for stomach adenocarcinoma based on its association with survival and clinicopathological features described in the study.
• Investigating the link between GLIS3 expression and epithelial-mesenchymal transition (EMT) marker switching in cancer cell lines as described in the functional studies.
• Studying the GLIS3–TGFBR3–Hedgehog signaling axis and its role in promoting cancer stem cell-like traits, as suggested by the mechanistic experiments.
• Validating transcriptomic findings from public datasets (TCGA, GEO) against protein-level data from a clinical tissue cohort.

Strengths

• Includes protein expression data from 133 paired clinical tissue samples, providing a direct clinical correlate.
• Links GLIS3 expression to specific clinical outcomes, including a reported hazard ratio of 1.45 for overall survival.
• Integrates findings from multiple public transcriptomic datasets (TCGA, GTEx, GEO) for validation.

Limitations

• Row count and specific column-level documentation are unknown, which may limit suitability assessment.
• The dataset is very small at 20.7 KB, suggesting limited scope, likely containing summary results rather than raw experimental data.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Qi Xiao

Collection Method

Data derived from immunohistochemistry on clinical tissues, public transcriptomic datasets (TCGA, GTEx, GEO), and functional cell line experiments.

Freshness

Last updated 2026-05-21 04:19:30; freshness should be verified.