Glycoengineering CAR-T Cells to Overcome Galectin-3-Mediated Immunosuppression

Public data mining, galectin-binding assessments, and glycomics identified galectin-3 as elevated in lymphoma microenvironments. The dataset likely contains results from experiments enforcing ST6GAL1 expression in anti-CD19 CAR-T cells to obstruct Gal-3 binding and improve anti-tumor responses. It was authored by Lee Seng Lau and last updated on March 17, 2026.

Use Cases

• Analyze the relationship between galectin-3 levels and lymphoma-associated microenvironments based on public data mining results.
• Model the impact of ST6GAL1 expression on CAR-T cell susceptibility to galectin-3-mediated regulation.
• Validate strategies to enhance CAR-T cell resistance in immunosuppressive microenvironments based on enforced sialylation experiments.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• Focus is on a specific, emerging mechanism in CAR-T cell therapy.

Limitations

• Dataset is very small at 22.5 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from public data mining, galectin-binding assays, and glycomics.

Freshness

Last updated 2026-03-17 13:06:47; freshness should be verified.