GPX7 emerged as the most consistently supported candidate linking stromal remodeling and innate immune activation in ulcerative colitis. The dataset likely contains expression data from integrated Mendelian randomization, transcriptomics, and single-cell RNA sequencing analyses. Author Jingui He published the data on figshare under a CC-BY-4.0 license in May 2026.
Use Cases
- Validate GPX7 as a biomarker for infliximab response based on its differential expression in responders and non-responders
- Analyze fibroblast-associated stromal-innate immune crosstalk based on GPX7-high mucosa enrichment for complement, chemokine, and extracellular matrix programs
- Investigate candidate modulator QL-X-138 using docking and molecular dynamics analyses described in the study
- Explore fibroblast-macrophage communication patterns based on the Transwell co-culture model results
Strengths
- Data integrates multiple orthogonal methods: two-sample Mendelian randomization, cross-cohort transcriptomics, and single-cell RNA sequencing
- Includes validation in an independent clinical cohort stratified by infliximab response
- Published under a CC-BY-4.0 license, allowing for broad reuse
Limitations
- Column-level documentation is absent; field semantics must be inferred after download
- Row count is unknown, which may limit suitability assessment
- The 1.2 MB file size suggests a relatively small dataset
Provenance
- Source
- figshare
- Collection Method
- Integrated Mendelian randomization, transcriptomics, single-cell RNA sequencing, qPCR validation, and co-culture models
- Freshness
- Last updated 2026-05-22 04:30:50