Scoping Review on Graft Rejection Mechanisms and Therapies in Solid Organ Transplantation

Edward Akosah Danso's scoping review synthesizes insights into graft rejection mechanisms and immunosuppressive strategies for solid organ transplants. The document, last updated in April 2026, is based on a systematic literature search following PRISMA guidelines across PubMed, Google Scholar, Cochrane, and ClinicalTrials.gov. It covers immunological mechanisms, organ-specific differences, and therapeutic innovations including conventional regimens, biologics, and emerging approaches.

Use Cases

• Literature review and synthesis based on the systematic search methodology described.
• Analysis of rejection mechanisms (hyperacute, acute, chronic) and their immunological basis as detailed in the results.
• Evaluation of immunosuppressive strategies, including conventional drugs, biologics, and emerging therapies mentioned in the review.
• Identifying research gaps in fields like vascularized composite allografts (VCA) and xenotransplantation highlighted in the aim.

Strengths

• Systematic literature search conducted following PRISMA guidelines, as stated in the methods.
• Includes quantitative clinical data points, such as acute rejection affecting 10%–20% of patients within the first year.
• Covers emerging fields like vascularized composite allografts (VCA) and xenotransplantation, as noted in the aim.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is a 12.4 KB DOCX file, indicating a limited scope likely containing a review document rather than raw data.

Provenance

Source

Edward Akosah Danso via figshare

Collection Method

Systematic literature search across PubMed, Google Scholar, Cochrane, and ClinicalTrials.gov.

Time Range

Literature search updated June 2025.

Freshness

Last updated 2026-04-20 05:22:37; freshness should be verified.

Geography

null