Terrisporobacter Association with Papillary Thyroid Carcinoma Risk

A figshare document presents research on the causal link between the gut microbe Terrisporobacter and papillary thyroid carcinoma (PTC). The analysis uses two-sample Mendelian randomization on large-scale GWAS data and validates findings in 450 PTC patients from The Cancer Genome Atlas. It identifies a causal odds ratio of 2.06 for PTC risk and correlations with NTRK1 upregulation and immunosuppressive tumor microenvironment features.

Use Cases

• Analyze the correlation between Terrisporobacter abundance and M2 macrophage infiltration (ρ = 0.25) in 450 TCGA PTC patient samples.
• Investigate the association of Terrisporobacter signals with NTRK1 oncogene expression levels (ρ = 0.35) as a potential driver of PTC progression.
• Validate the Mendelian randomization-derived odds ratio (OR = 2.06) for Terrisporobacter and PTC risk using clinical cohort data.
• Examine the relationship between microbial abundance and CD8+ T cell depletion (ρ = -0.19) within the tumor immune microenvironment.

Strengths

• Causal inference is supported by a two-sample Mendelian randomization analysis on large-scale GWAS data.
• Validation cohort includes 450 papillary thyroid carcinoma patients from The Cancer Genome Atlas.
• Findings are supported by in vitro experiments confirming mechanistic links between Terrisporobacter and PTC cell behavior.

Limitations

• The primary data is a 17.7 KB DOCX file summarizing results, not the raw underlying tabular or genomic datasets.
• Sample size for the clinical validation cohort is limited to 450 patients from a single source (TCGA).
• The dataset's scope is narrowly focused on one microbial genus (Terrisporobacter) and one cancer type (PTC).

Provenance

Source

figshare, authored by Jia Li.

Collection Method

Multi-stage study employing Mendelian randomization, analysis of TCGA patient data, and in vitro experiments.

Freshness

Last updated March 25, 2026.