Gut Microbial IgA Coating in Infants from Farming and Urban Cohorts

30 infant stool samples from a traditional farming (OOM) and an urban (ROC) cohort were analyzed using IgA-SEQ at an average age of 6 months. The dataset, authored by Kevin Bu and last updated in April 2026, compares IgA coating levels of gut bacteria like Bifidobacterium and Ruminococcus with allergic outcomes diagnosed over the first 2 years of life.

Use Cases

• Identify microbial taxa associated with allergic outcomes based on differential IgA coating levels.
• Study the relationship between infant age and IgA coating of specific bacterial genera like Atopobium and Corynebacterium.
• Investigate the association between breastfeeding, fecal IgA levels, and maternal milk IgA response to commensals like B. infantis.
• Compare gut microbiome composition and immune interactions between traditional farming and urbanized infant populations.

Strengths

• Includes data from two distinct cohorts with contrasting allergy prevalences (40% vs. <2%).
• Contains longitudinal allergic outcome diagnoses tracked over the first 2 years of life.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (20.2 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Immunoglobulin A sequencing (IgA-SEQ) performed on stool samples.

Time Range

Samples collected at an average of 6 months; outcomes tracked for 2 years.

Freshness

Last updated 2026-04-20 05:23:34; freshness should be verified.

Geography

Infants from an urban Rochester (ROC) cohort and a traditional Old Order Mennonite (OOM) community.