Systematic Review of Gut Microbiome Differences in Rheumatoid Arthritis by Serostatus

Eight studies published between 2016 and 2024 systematically review gut microbiome differences in rheumatoid arthritis patients by serological status. The review analyzes findings on microbial abundances, α-diversity, and β-diversity, comparing seropositive and seronegative RA patients and healthy controls. It was authored by Madiyar Nurgaziyev and registered with PROSPERO.

Use Cases

• Analyze reported associations between serostatus (RF/ACPA) and specific microbial abundances like Collinsella, Blautia, and Faecalibacterium.
• Compare α-diversity and β-diversity findings across studies to assess consistency in microbial diversity differences by serostatus.
• Investigate temporal patterns by examining results segmented by disease stage (preclinical/early vs. established RA).
• Use the systematic review's extracted data to identify gaps for future standardized studies on microbiome biomarkers in RA.

Strengths

• Findings are synthesized from eight distinct observational studies, providing a consolidated evidence base.
• Review covers a 9-year publication span (2016-2024) of relevant research.
• Study quality was formally assessed using the Newcastle–Ottawa Scale (NOS).
• Data extraction was performed independently by two reviewers to reduce bias.

Limitations

• The dataset is a 16.0 KB document summarizing findings, not the raw underlying study data.
• Only eight studies met the inclusion criteria, indicating a limited primary evidence pool.
• Findings for β-diversity were reported as heterogeneous, showing no clear consensus across cohorts.

Provenance

Source

figshare, authored by Madiyar Nurgaziyev.

Collection Method

Systematic literature review of PubMed, Scopus, Web of Science, and Cochrane Library.

Time Range

Studies published between 2016 and 2024, searched through July 2025.

Freshness

Last updated March 2026, covering literature through July 2025.

Geography

null