HALP Index and Mortality Across Metabolic Syndrome Spectrum: NHANES 1999-2010

10,770 adult participants from the NHANES 1999–2010 surveys were followed through 2019 to examine the association between the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) index and mortality across the continuous metabolic syndrome (cMetS) spectrum. The dataset, authored by Keting Deng and published on figshare in 2026, contains results from survey-weighted Cox regression and competing-risk analyses. It includes hazard ratios, 10-year mortality risk percentages, and Harrell’s C statistics for model discrimination.

Use Cases

• Assessing the nonlinear association between the HALP index and all-cause mortality based on hazard ratios and tertile analysis.
• Evaluating the joint prognostic value of HALP and continuous metabolic syndrome (cMetS) scores for cardiovascular mortality risk.
• Validating a routine clinical index for systemic vulnerability using external cohort evidence mentioned in the description.
• Conducting decision curve analysis to assess the net benefit of adding HALP to existing risk models.

Strengths

• Includes data from 10,770 participants from a nationally representative survey (NHANES).
• Provides specific hazard ratios and confidence intervals (e.g., HR 0.78, 95% CI 0.69–0.88) for mortality associations.
• Reports 10-year mortality risk percentages for HALP tertiles (e.g., 15.4% in the lowest tertile).
• Uses multiple analytical methods including restricted cubic splines, competing-risk models, and external validation.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying analytical dataset is unknown, which may limit suitability assessment.
• The primary file format is DOC (15.5 KB), which suggests the data may be presented in summary tables rather than a raw, analyzable dataset.

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) 1999-2010, with supportive external cohort evidence.

Collection Method

Survey-weighted Cox regression with restricted cubic splines, adjusting for covariates.

Time Range

NHANES data from 1999–2010, with mortality follow-up through December 31, 2019.

Freshness

Last updated 2026-05-20 05:38:43; freshness should be verified.

Geography

United States (NHANES).