HDAC7 Regulation of CD8+ T Cell Function in Mouse Models

A dataset from a study investigating the role of histone deacetylase 7 (HDAC7) in peripheral CD8+ T cell function. The data likely contains measurements from murine models of lymphoma and viral infection, examining immune checkpoint expression, apoptosis, and glutamine homeostasis. The dataset was authored by Cansu Yerinde and last updated on May 12, 2026.

Use Cases

• Analyze the relationship between HDAC7 deficiency and immune checkpoint molecule expression based on the described upregulation.
• Investigate T cell apoptosis pathways based on the described link to MEF2D-dependent FasL induction.
• Study glutamine metabolism in T cells based on the described disturbed homeostasis.
• Evaluate anti-tumor immune responses in syngeneic lymphoma transfer models based on the described impaired responses.
• Assess memory recall responses in viral infection models based on the described requirement for HDAC7.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• The study description provides a clear biological hypothesis and experimental models.

Limitations

• The dataset is small in size (250.3 KB), indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data likely generated from laboratory experiments on genetically modified mice.

Freshness

Last updated 2026-05-12 04:19:00; freshness should be verified.