Table 1: HDAC8 and Tight Junction Protein Data from Allergic Rhinitis Study

Table 1_HDAC8 impairs tight junctions in allergic rhinitis through Smad7 deacetylation.docx contains data from a study on allergic rhinitis. The dataset likely includes protein expression levels for HDAC8, Smad7, acetyl-Smad7, and tight junction proteins ZO-1, Occludin, and Claudin-1 from primary human nasal epithelial cells and a house dust mite-induced mouse model. The data was uploaded by Huan-huan Chang on figshare and last updated on 2026-05-01.

Use Cases

• Analyze the correlation between HDAC8 expression and tight junction protein disruption based on protein expression data.
• Investigate the effect of pharmacological HDAC8 inhibition (PCI-34051) on Smad7 acetylation status based on experimental results.
• Validate the role of Smad7 acetylation-mimetic mutants in rescuing tight junction integrity based on mutant analysis data.
• Compare cytokine profiles (Th1/Th2/Th17/Treg) between treated and untreated allergic rhinitis models based on ELISA data.

Strengths

• Data is derived from both primary human nasal epithelial cells and an established house dust mite-induced mouse model.
• Includes results from multiple experimental interventions: HDAC8 overexpression, siRNA knockdown, and pharmacological inhibition.
• Analyzes protein-protein interactions via co-immunoprecipitation and expression via western blot.

Limitations

• The dataset is very small at 16.9 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Huan-huan Chang via figshare

Collection Method

Experimental data from cell culture and mouse model studies, analyzed by co-immunoprecipitation, western blot, histology, and ELISA.

Freshness

Last updated 2026-05-01 05:27:31; freshness should be verified.