Hepatic Zinc Deficiency and Acute Phase Response in Alcohol-Associated Hepatitis

A transcriptomic zinc signature derived from 11 public datasets, validated in vitro, identifies hepatic zinc deficiency in patients with alcohol-associated hepatitis. The dataset, published by Scott A. Read on figshare, is associated with a down-regulation of the acute phase response pathway. It was last updated on March 18, 2026.

Use Cases

• Identify hepatic zinc deficiency based on a nine-gene transcriptomic signature mentioned in the description
• Analyze the correlation between zinc deficiency and dampened acute phase response (e.g., SAA1, CRP, C9 genes) in liver disease
• Validate transcriptomic findings using in vitro models of hepatocyte and immune cell cultures described in the methods

Strengths

• Derived from 11 publicly available transcriptomic datasets, providing a multi-source foundation.
• Includes in vitro validation using primary immune cell and hepatocyte models, as described in the methods.
• File size is 25.4 MB, indicating a manageable download and analysis scale.

Limitations

• Row count and specific column definitions are unknown, limiting suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect bias inherent to the specific public datasets aggregated for the analysis.

Provenance

Source

figshare, author Scott A. Read

Collection Method

Bioinformatic analysis of public datasets combined with in vitro cell culture validation.

Freshness

Last updated 2026-03-18 07:36:49