Table 1_Hereditary α-tryptasemia; a review of mechanisms linking α-tryptase gene dosage to

Ilaria M. Simeone's 2026 review synthesizes evidence on Hereditary α-tryptasemia (HαT), a genetic trait affecting 4%–6% of individuals of European ancestry. The 17.6 KB document discusses HαT as a disease modifier in gastrointestinal conditions like celiac disease and inflammatory bowel disease. It is available on figshare under a CC-BY-4.0 license.

Use Cases

• Literature review on the clinical impact of α-tryptase gene dosage based on the synthesized evidence.
• Studying mast cell behavior in gastrointestinal disease contexts based on the review's discussion of MC activation and MRGPRX2 expression.
• Investigating genetic modifiers of celiac disease and IBD outcomes based on the described associations with HαT.

Strengths

• Provides a focused review on a specific genetic trait (HαT) identified in 2015.
• Cites specific prevalence figures (4%–6% of individuals of European ancestry).
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Dataset is a 17.6 KB text document, not a structured data file.
• Row count and column-level documentation are absent.
• The data may reflect a specific review perspective rather than raw experimental data.

Provenance

Source

Ilaria M. Simeone via figshare.

Collection Method

Likely a literature review and synthesis of published research.

Time Range

Review published in 2026, covering research from 2015 onward.

Freshness

Last updated 2026-04-14.

Geography

Focus includes individuals of European ancestry; broader geographic applicability is not specified.