Gut Microbiome Profiles for Parkinson's Disease and Insomnia Study

A clinical dataset of gut microbiome profiles from 310 participants, including 185 Parkinson's disease patients and 125 controls, categorized by insomnia status. The data was generated by Sheng-Hsuan Lin using 16S rRNA sequencing and processed with DADA2 and the SILVA database. It was last updated on 2026-05-05.

Use Cases

• Compare alpha and beta diversity metrics between PD patients and controls based on insomnia status mentioned in the description
• Identify differential abundance of bacterial genera associated with insomnia in different disease contexts
• Analyze predicted functional pathways (e.g., via PICRUSt2) that differ between PD and non-PD individuals with insomnia
• Investigate disease-context moderation in microbiome-sleep relationships as highlighted in the study results

Strengths

• Includes data from 310 participants with clear group sizes (185 PD patients, 125 controls)
• Microbiome profiles were generated using a standardized method (16S rRNA sequencing, DADA2, SILVA database)
• Analysis adjusted for relevant confounders, as stated in the methods

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The 1.8 MB file size suggests a small dataset, potentially containing summary results rather than raw sequence data

Provenance

Source

Sheng-Hsuan Lin via figshare

Collection Method

16S rRNA sequencing of gut microbiome, processed with DADA2 using the SILVA database for taxonomic assignment.

Freshness

Last updated 2026-05-05 05:24:46; freshness should be verified