Table 1_High-protein supplementation in critically ill patients: a systematic review, meta

A 2026 systematic review and meta-analysis by Zhiming You, synthesizing evidence from 18 randomized controlled trials and 8 meta-analyses published up to April 1, 2026. The dataset, a 13.9 MB document, examines the effects of high-protein versus conventional protein supplementation on mortality and other clinical outcomes in critically ill patients. It includes results from meta-analysis, subgroup analysis, umbrella review, and Trial Sequential Analysis.

Use Cases

• Conducting a meta-analysis on protein supplementation and mortality based on the included 18 RCTs.
• Performing subgroup analysis on intervention duration based on the finding that long-term (>14 days) intake may increase mortality.
• Validating meta-analysis results using Trial Sequential Analysis (TSA) methods described in the review.
• Assessing the quality of existing evidence using the AMSTAR-2 and ROB 2.0 tools referenced in the methodology.

Strengths

• Includes results from 18 randomized controlled trials and 8 meta-analyses, providing a structured evidence synthesis.
• Employs multiple analytical methods: meta-analysis, subgroup analysis, umbrella review, and Trial Sequential Analysis.
• Uses established quality assessment tools (ROB 2.0, AMSTAR-2) for bias risk evaluation.

Limitations

• The primary data is a 13.9 MB DOCX document; column-level data and row counts for underlying studies are unavailable.
• Freshness should be verified as the last update was 2026-05-21 04:35:59.
• The dataset's scale is limited to the synthesized evidence from the included studies; raw patient-level data is not provided.

Provenance

Source

figshare, authored by Zhiming You.

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, Cochrane Library, and Embase.

Time Range

Studies included up to April 1, 2026.

Freshness

Last updated 2026-05-21 04:35:59.