Plasma Fatty Acids and Dementia Risk in UK Biobank Participants

A 12.1-year median follow-up study of 81,827 UK Biobank participants investigates associations between plasma omega-3 and omega-6 fatty acids, Alzheimer's disease polygenic risk, and incident dementia. The dataset includes baseline NMR metabolomics and genetic information, with incident dementia identified through linked hospital and death records. It was authored by Li Luo and last updated in May 2026.

Use Cases

• Modeling dementia risk based on plasma omega-6 fatty acid concentrations
• Investigating gene-nutrient interactions using Alzheimer's disease polygenic risk scores
• Validating NMR metabolomics biomarkers for neurodegenerative disease prediction

Strengths

• Large cohort of 81,827 participants with linked genetic and metabolomic data
• Longitudinal design with a median follow-up of 12.1 years and 1,335 incident dementia cases
• Standardized NMR spectroscopy for plasma fatty acid quantification

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

UK Biobank

Collection Method

Data analyzed from UK Biobank participants with baseline NMR metabolomics and genetic information.

Time Range

Median follow-up of 12.1 years

Freshness

Last updated 2026-05-14 05:23:36; freshness should be verified

Geography

United Kingdom