Hippocampal Neuronal Data from an EAE Mouse Model of MS

Experimental data from the EAE mouse model links hippocampal neuronal hypoexcitability to PTSD-like phenotypes. The dataset, created by Xinghua Zhong and last updated in May 2026, includes results from morphometric analysis, whole-cell recordings, chemogenetic manipulation, and single-nucleus RNA sequencing. It is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Modeling the relationship between neuronal firing gain and fear extinction deficits based on whole-cell recording data.
• Analyzing transcriptional shifts in excitatory neurons based on single-nucleus RNA sequencing results showing immune and apoptosis-related gene signatures.
• Investigating structural correlates of behavioral phenotypes based on morphometric analysis of somatic atrophy in CA1 pyramidal neurons.
• Testing therapeutic hypotheses for restoring hippocampal excitability based on chemogenetic manipulation results.

Strengths

• Data integrates multiple experimental modalities: morphometry, electrophysiology, chemogenetics, and single-nucleus RNA-seq.
• Findings are linked to two core behavioral phenotypes: impaired fear extinction and contextual fear generalization.
• Dataset is openly shared under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is small in scale at 174.3 KB, indicating a limited scope of data points.
• Data is derived from a specific mouse model (EAE), and direct applicability to human MS patients requires further validation.

Provenance

Source

figshare, author Xinghua Zhong.

Collection Method

Data was gathered using the experimental autoimmune encephalomyelitis (EAE) mouse model, employing morphometric analysis, whole-cell recordings, chemogenetic manipulation, and single-nucleus RNA sequencing.

Freshness

Last updated 2026-05-20 13:23:09.