Hnrnpa1 Knockout Zebrafish: Phenotypic and Metabolic Profiling Data

5.9 MB of data from a novel zebrafish knockout model for RNA binding proteins Hnrnpa1 and Hnrnpa3, authored by Lara U. Jansen. The dataset includes results showing that double mutants of hnrnpa1a and hnrnpa1b are embryonic lethal with muscle, vascular, and developmental defects. Metabolic profiling revealed severe changes in lipid metabolism, identifying Hnrnpa1's role in multiple cellular pathways.

Use Cases

• Study embryonic lethality and developmental defects based on the described knockout phenotypes.
• Analyze changes in lipid metabolism based on the metabolic profiling results.
• Investigate the physiological roles of Hnrnpa1 and Hnrnpa3 in early development.
• Explore potential therapeutic pathways for HNRNPA-associated diseases.

Strengths

• Data is from a novel zebrafish knockout model, providing a specific genetic tool.
• Includes metabolic profiling data revealing changes in lipid metabolism.
• Released under a CC-BY-4.0 license, allowing for broad reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from zebrafish knockout studies and metabolic profiling.

Freshness

Last updated 2026-06-01 05:36:17; freshness should be verified.