Homocysteine and Cognitive Function in Depression: Meta-Analysis Results

Xiaotong Liu's systematic review and meta-analysis assesses the association between homocysteine levels and cognitive function in depression. The analysis includes 13 studies involving 1,269 patients, reporting correlation and standardized mean difference statistics. The work was last updated on 2026-05-13 and is shared under a CC-BY-4.0 license.

Use Cases

• Conducting secondary meta-analysis based on reported correlation and SMD statistics
• Investigating biochemical markers for cognitive impairment based on the described homocysteine association
• Designing prospective clinical studies based on the review's conclusions

Strengths

• The meta-analysis is based on 13 studies involving 1,269 patients, providing a defined sample size.
• Methodological quality was assessed using the AHRQ checklist and evidence certainty with the GRADE approach.
• Results include specific statistical measures: r = -0.41 and SMD = 2.44 with confidence intervals.

Limitations

• The dataset is a 14.1 KB DOCX file, suggesting it contains summary text and tables rather than raw participant-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for data-driven modeling.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, Wanfang Data, and VIP databases.

Time Range

Studies from database inception to December 2025.

Freshness

Last updated 2026-05-13 05:57:12