Homocysteine and Cognitive Function in Depression: Meta-Analysis Results

13 studies involving 1,269 patients with depression were included in this systematic review. The meta-analysis shows a significant inverse association between homocysteine levels and cognitive scores (r = −0.41). The dataset was created by Xiaotong Liu and last updated in May 2026.

Use Cases

• Assess the association between homocysteine levels and cognitive scores based on the reported correlation coefficient
• Compare cognitive performance between patients with and without impairment based on the standardized mean difference (SMD)
• Validate the consistency of the homocysteine-cognition link using the described subgroup and sensitivity analyses

Strengths

• Includes results from 13 studies with a total of 1,269 patients
• Reports specific statistical measures including correlation coefficients (r) and standardized mean differences (SMD) with confidence intervals
• Methodological quality was assessed using the AHRQ checklist and GRADE approach

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The 14.1 KB file size indicates a very limited data scope, likely containing only summary statistics

Provenance

Source

Xiaotong Liu

Collection Method

Systematic review and meta-analysis of studies from PubMed, Web of Science, EMBASE, Cochrane Library, CNKI, Wanfang Data, and VIP databases.

Time Range

Studies from inception to December 2025

Freshness

Last updated 2026-05-13 05:51:55