Hongjam Silkworm Food Effects on Liver Disease in Mouse Model

A 2026 study by Hye-Rin Ahn investigates the hepatoprotective effects of Hongjam, an edible silkworm-derived food, in a mouse model of metabolic dysfunction-associated steatohepatitis (MASH). The research includes histological analysis, plasma biochemical assessments, western blotting, quantitative PCR analyses, and in vitro experiments using macrophages and HepG2 cells. The findings demonstrate that Hongjam attenuates experimental MASH by modulating metabolic stress, inflammation, and fibrotic remodeling.

Use Cases

• Analyze the effects of a food-derived candidate on liver injury based on histological features and plasma biochemical parameters.
• Study the modulation of TGF-β/Smad and NF-κB signaling pathways based on in vivo and in vitro experimental results.
• Investigate the attenuation of metabolic stress signaling based on changes in AMPK phosphorylation and gene expression.
• Evaluate the potential of silk fibroin peptides for dietary strategies targeting metabolic liver diseases.

Strengths

• The study includes both in vivo mouse model data and in vitro cell experiments.
• The description provides a detailed mechanistic explanation of the intervention's effects.
• The dataset is openly licensed under CC-BY-4.0.

Limitations

• The dataset is a 20.7 KB DOCX file, indicating a limited scope likely containing summary text rather than raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Experimental research involving a methionine-choline-deficient (MCD) diet-induced mouse model.

Freshness

Last updated 2026-05-26 04:39:12; freshness should be verified.