Hoxb4 Upregulation by Xuan Bi Tong Yu Fang in Myocardial Ischemia-Reperfusion Injury

36 Wistar rats were used to study the cardioprotective effects of the Traditional Chinese Medicine formula Xuan Bi Tong Yu Fang (XBTYF) against myocardial ischemia-reperfusion injury (MIRI). Bulk RNA-seq data and in vitro experiments on H9C2 cardiomyocytes suggest the mechanism involves Hoxb4 upregulation and Wnt/β-catenin pathway repression. The dataset, authored by Peng-fei Li and last updated in May 2026, is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Identify differentially expressed genes in MIRI based on bulk RNA-seq data mentioned in the description
• Analyze the relationship between Hoxb4 expression and Wnt/β-catenin pathway activity based on described in vitro experiments
• Study the effects of multi-dose herbal treatment on myocardial enzyme levels and infarction area based on the described rat model
• Investigate molecular docking interactions between herbal compounds like ginsenoside Rg3 and the Hoxb4 protein

Strengths

• Experimental data from a controlled study with 36 Wistar rats across 6 treatment groups
• Multi-modal analysis combining in vivo, in vitro, RNA-seq, and molecular docking data as described
• Dataset is openly shared under a permissive CC-BY-4.0 license

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download
• The dataset is small at 91.3 KB, indicating limited scope or summary-level data
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory experiments on rat models and H9C2 cardiomyocyte cell lines, as described.

Freshness

Last updated 2026-05-07 04:45:16; freshness should be verified