TDP-43 ALS Pathogenesis Review: iPSC-Derived Motor Neuron Models

A 12.7 KB Excel file summarizing recent research on TDP-43-related amyotrophic lateral sclerosis. The review, authored by Satoshi Yokoi and last updated in May 2026, discusses the use of human iPSC-derived motor neurons as a platform for modeling ALS pathogenesis. It focuses on TDP-43 protein dynamics, cryptic exon inclusion, and future research directions like longitudinal and co-culture analyses.

Use Cases

• Reviewing recent advances in TDP-43-related ALS models based on the described literature summary.
• Identifying key challenges in generating faithful ALS pathogenesis models as discussed in the review.
• Planning future research involving longitudinal TDP-43 dynamics analysis based on the proposed perspectives.

Strengths

• File is small (12.7 KB) and likely easy to download and open.
• Dataset is openly licensed under CC-BY-4.0.
• Author and specific last update date (2026-05-22) are provided.

Limitations

• Row count and column structure are unknown, limiting suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a summary table from a review article, not primary experimental data.

Provenance

Source

figshare, author Satoshi Yokoi.

Collection Method

Likely a manually compiled summary table from a literature review.

Freshness

Last updated 2026-05-22 06:09:41; freshness should be verified.