IgA Nephropathy Model Data on Renal Injury, Gut Microbiota, and Inflammatory Markers

Yuanyuan He published data on figshare in June 2026 under a CC-BY-4.0 license. The dataset likely contains measurements from a study of human umbilical cord mesenchymal stem cell–derived exosomes in an IgA nephropathy-like mouse model. It includes assessments of renal function, histopathology, systemic inflammatory markers, and gut microbiota composition analyzed via 16S rRNA sequencing.

Use Cases

• Correlating gut microbial taxa like Anaerostipes, Dorea, and Ruminococcus with renal dysfunction indicators.
• Analyzing changes in NLRP3 inflammasome-related gene expression from human IgAN glomeruli transcriptomic data.
• Investigating associations between exosome treatment and levels of inflammatory markers IL-1β and IL-18 in stimulated podocytes.
• Exploring microbial co-occurrence networks constructed from 16S rRNA sequencing data.

Strengths

• Data integrates multiple biological levels: renal injury markers, gut microbiota composition, and inflammatory signaling.
• Includes transcriptomic analysis of human IgAN glomeruli from a public dataset (GSE93798).
• The dataset is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is small at 52.1 KB, suggesting limited scope or summary-level data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The authors note observations are descriptive and associative, with causal mechanisms not inferable.

Provenance

Source

Yuanyuan He via figshare.

Collection Method

Data generated from an IgAN-like mouse model study, in vitro podocyte experiments, and analysis of public human transcriptomic data.

Freshness

Last updated 2026-06-01 04:17:35.