Huoxue Jiegu Compound Capsule: Molecular Mechanisms in Tibial Fracture Healing

Huoxue Jiegu Compound Capsule (HXJGCC) data comprises results from an integrative study combining network pharmacology, molecular dynamics simulations, and in vivo experiments. The dataset includes 209 candidate bioactive compounds, 185 overlapping therapeutic targets, and in vivo qRT-PCR results for angiogenesis-associated genes. The data was authored by Weisong Lu and last updated on May 11, 2026.

Use Cases

• Validate network pharmacology predictions based on identified hub targets like AKT1, STAT3, IL6, BCL2, EGFR, and JUN.
• Study angiogenesis-related signaling pathways based on enrichment in HIF-1, PI3K–Akt, Relaxin, TNF, and FoxO pathways.
• Correlate molecular docking stability with in vivo vascular density outcomes based on the described multi-component, multi-target mechanism.
• Investigate the neuro–vascular–bone interaction framework for bone regeneration based on the proposed angiogenesis-driven repair model.

Strengths

• Integrates multiple methodological approaches: network pharmacology, molecular docking, 100-ns molecular dynamics simulations, and in vivo validation.
• Identifies a specific set of 209 candidate active compounds and 185 overlapping targets for mechanistic analysis.
• In vivo experimental results include quantitative measures such as vascular density and qRT-PCR gene expression data.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 23.7 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Data generated through an integrative research strategy combining computational and experimental validation.

Freshness

Last updated 2026-05-11 05:29:08; freshness should be verified.