Table 1_HYAL3 as a therapeutic target for pulmonary arterial Hypertension–Cardiomyopathy c

A 2026 study by Jianchuan Hu identifies 14,403 genes common to pulmonary arterial hypertension and cardiomyopathy. The research employs weighted gene co-expression network analysis and machine learning to highlight four diagnostic hub genes, with experimental validation of HYAL3. The dataset includes results from molecular docking simulations proposing flurbiprofen as a candidate therapeutic agent.

Use Cases

• Identifying diagnostic biomarkers for pulmonary arterial hypertension-cardiomyopathy comorbidity based on the four highlighted hub genes (HYAL3, ADIPOQ, ZNF852, SCD).
• Training machine learning models for disease classification using the gene co-expression modules identified via WGCNA.
• Conducting virtual drug screening for HYAL3 inhibitors based on the molecular docking and dynamics simulation results.
• Analyzing upstream regulatory networks involving transcription factors like FOXL1, FOXC1, and PPARG mentioned in the study.

Strengths

• Identifies 14,403 genes common to two diseases, providing a broad molecular basis for analysis.
• Hub genes demonstrated excellent diagnostic value with an area under the curve exceeding 0.9.
• Key findings were experimentally validated in vitro using hypoxia-induced HPAECs and angiotensin II-induced H9C2 cardiomyocytes.
• Results include molecular dynamics simulations demonstrating stable binding for a proposed therapeutic candidate.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (14.7 KB), indicating limited scope, likely containing summary results rather than raw data.

Provenance

Source

figshare, author Jianchuan Hu.

Collection Method

Integrative analysis of public databases combined with machine learning (WGCNA, SHAP) and experimental validation.

Time Range

Study published in 2026.

Freshness

Last updated 2026-04-10 06:00:03; freshness should be verified.

Geography

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