Table 1_Hybrid plasmids: genetic diversity and hypervirulent phenotype of Klebsiella pneum

32 Klebsiella pneumoniae isolates from Russian hospitals were sequenced, revealing that 27 carried large hybrid plasmids (272–476 kb) co-harboring virulence and antibiotic resistance genes. The dataset includes results from a mouse lethality assay and a global cluster analysis of 295 hybrid plasmids, identifying 8 distinct groups. This research, published by Svetlana Kovalchuk under CC-BY-4.0, investigates the contradictory link between these plasmids and hypervirulence.

Use Cases

• Analyzing the genetic structure of hybrid plasmids based on the described virulence and resistance gene content.
• Training models to predict plasmid clusters based on replicon type and gene profiles mentioned in the study.
• Investigating the association between specific sequence types (ST147, ST395, ST11) and hybrid plasmid carriage.
• Benchmarking virulence assessment methods using the provided mouse LD50 assay results.

Strengths

• Includes whole-genome sequencing data for 32 isolates, with 27 confirmed to carry hybrid plasmids.
• Provides a comparative global analysis of 295 hybrid plasmids, identifying 8 clusters.
• Links genetic data (plasmid sequences, gene content) to phenotypic virulence assay results (LD50 values).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect geographic bias inherent to the collection from eight Russian hospitals.

Provenance

Source

Svetlana Kovalchuk via figshare.

Collection Method

Whole-genome sequencing of clinical and environmental isolates, mouse lethality assays, and bioinformatic cluster analysis.

Time Range

Collection period not specified in the provided metadata.

Freshness

Last updated 2026-04-29 06:02:28; freshness should be verified.

Geography

Isolates recovered from eight hospitals in Russia.