Hyperglycemia-Induced Immune Tolerance in Human Alveolar Macrophages

A research document from figshare describes a study on immune tolerance in alveolar macrophages from diabetic patients. The work analyzes metabolic profiles, transcriptional, and epigenetic reprogramming using techniques like Seahorse, LC-MS, RNA-seq, ATAC-seq, and CUT&Tag. The dataset is 19.4 KB and was last updated on May 7, 2026.

Use Cases

• Study the link between hyperglycemia and pulmonary infection susceptibility based on macrophage immune memory phenotypes.
• Analyze metabolic reprogramming in immune-tolerant cells based on oxidative phosphorylation and lipid metabolism data.
• Investigate epigenetic modifications associated with immune tolerance based on chromatin accessibility and H3K4me3 profiles.
• Identify candidate immunomodulatory targets for diabetic complications based on transcriptional analysis of autophagy and apoptosis genes.

Strengths

• The study uses primary human alveolar macrophages from patients with diabetes.
• Analysis integrates multiple high-resolution techniques: Seahorse, LC-MS metabolomics, RNA-seq, ATAC-seq, and CUT&Tag.
• The dataset is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is a 19.4 KB DOCX file, suggesting limited scope and likely containing summary text rather than raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

Primary human alveolar macrophages were isolated from patients with diabetes; an in vitro hyperglycemia-induced immune memory model was established.

Freshness

Last updated 2026-05-07 04:45:51; freshness should be verified.