Hyperoxia-Induced BPD Study: Gene Expression and Senescence Analysis

19.7 KB of research data from a study linking hyperoxia to bronchopulmonary dysplasia via the Noggin-BMP4 signaling axis. The dataset, authored by Jiaxin Zhang and last updated in April 2026, includes findings from bioinformatics analysis and in vitro/in vivo experiments, showing a 2.5-fold increase in Noggin mRNA and a 50% reduction in BMP4 protein under hyperoxic conditions.

Use Cases

• Validate the Noggin-BMP4 axis as a therapeutic target for BPD based on the described gene expression changes.
• Model p53/p21-mediated cellular senescence pathways using the reported fold-change data.
• Cross-reference transcriptomic signatures of BPD with aging-related databases as performed in the study.

Strengths

• Includes specific quantitative results, such as a 2.5-fold mRNA increase and a 2.0-fold protein increase for Noggin.
• Integrates findings from multiple experimental models: bioinformatics (WGCNA), in vitro cell studies, and a neonatal rat model.
• Released under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• The dataset is very small at 19.7 KB, suggesting limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Data generated through bioinformatics analysis (WGCNA) and laboratory experiments on human pulmonary microvascular endothelial cells (HPMECs) and a neonatal rat model.

Time Range

Study period not specified; dataset last updated in 2026.

Freshness

Last updated 2026-04-20 04:13:15; freshness should be verified.

Geography

Geographic origin of the data or subjects is not specified.