Hypobaric Hypoxia Effects on Lung Dendritic and T-Cell Data

49.5 KB of experimental results detail how hypobaric hypoxia increases lung dendritic cells and promotes T-cell immunosuppression in rodent models of high-altitude pulmonary edema (HAPE). The data, generated by Xuemei Wei and published in 2026, includes findings from single-cell sequencing, flow cytometry, and in vivo cytokine injections.

Use Cases

• Analyze the correlation between hypobaric hypoxia exposure and the measured increase in lung dendritic cell counts from rodent models.
• Model the immunosuppressive effect on CD4+ T cells, specifically CD4+CD25+ subsets, using flow cytometry and cytokine data.
• Investigate the role of TNF-α injection on dendritic cell recruitment and IL-6 production levels in HAPE pathophysiology.
• Validate the protective role of CD4+ T cells using data from experiments with neutralizing antibodies in mice.

Strengths

• Data is derived from controlled experimental models including rats and TNF-α-deficient mice.
• Findings are supported by multiple methodologies: single-cell sequencing, flow cytometry, and in vitro co-culture.
• Published under a permissive CC BY 4.0 license in 2026, indicating recent research.

Limitations

• The dataset is very small at 49.5 KB, limiting the scope for extensive statistical or machine learning analysis.
• Data is contained within a DOC file format, which is not ideal for direct computational analysis and may require manual extraction.
• Findings are specific to rodent models, and direct applicability to human physiology may be limited.

Provenance

Source

figshare, authored by Xuemei Wei.

Collection Method

Experimental data from single-cell sequencing, flow cytometry, in vitro co-culture, and in vivo injections in rodent models.

Freshness

Last updated on 2026-03-24.